Institute of Bioinformatics WWU Münster
Claim

Translation initiation sites that precede the main coding sequence (CDS) of a transcript give rise to upstream open reading frames (uORFs). The presence of uORFs affects initiation rates at the CDS by interfering with unrestrained progression of ribosomes across the 5ยด-transcript leader sequence.

 

Accumulating evidence suggests that uORF-mediated translational control is of outstanding importance for the regulation of protein expression in health and disease.

uORFdb

  • aims to collect all literature on uORF biology in eukaryotic organisms, including viral transcripts
  • categorizes individual uORF-related publications by a variety of denominators, including taxon, gene, and the type of study. [read more]
  • can be queried for multiple structural and functional uORF-related properties to allow convenient and targeted access to the complex field of uORF biology

The current version (v1.01, 2013/12/15) provides links to 500 references in PubMed addressing uORF functions in various taxa and genes as summarized below [read more]

NAR Paper

Nucleic Acids Res. 2014 Jan;42(Database issue):D60-7. doi: 10.1093/nar/gkt952. Epub 2013 Oct 24. uORFdb -- a comprehensive literature database on eukaryotic uORF biology. Wethmar K, Barbosa-Silva A, Andrade-Navarro MA, Leutz A. - see here