Institute of Bioinformatics Münster
Translation initiation sites that precede the main coding sequence (CDS) of a transcript give rise to upstream open reading frames (uORFs). The presence of uORFs affects initiation rates at the CDS by interfering with unrestrained progression of ribosomes across the 5ยด-transcript leader sequence.
Accumulating evidence suggests that uORF-mediated translational control is of outstanding importance for the regulation of protein expression in health and disease. It has the following visions:
  • aims to collect all literature on uORF biology in eukaryotic organisms, including viral transcripts
  • categorizes individual uORF-related publications by a variety of denominators, including taxon, gene, and the type of study. [read more]
  • can be queried for multiple structural and functional uORF-related properties to allow convenient and targeted access to the complex field of uORF biology
Current Number of Publications
Current Number of Genes
The current numbers are based on the data from 2020-05-25 14:15
Reference Paper: Nucleic Acids Res. 2014 Jan;42(Database issue):D60-7. doi: 10.1093/nar/gkt952. Epub 2013 Oct 24. uORFdb -- a comprehensive literature database on eukaryotic uORF biology. Wethmar K, Barbosa-Silva A, Andrade-Navarro MA, Leutz A. - see here