With uORFdb we aim to merge expert annotations of the latest uORF literature with the crucial sequence context of individual uORFs in humans and 12 other species. At present, the database contains more than 1,040 manually curated publications and more than 6.6 million uORFs of which over 2.4 million are located on human transcripts. For human uORFs, you can access information on genetic variability via external databases (e.g. dbSNP and ClinVar) and at the level of individual studies (e.g. WGS data of cancer patients). Currently, the database contains more than 129,000 somatic variant positions identified in WGS data of patient cohorts from breast, colon, blood, lung, prostate and skin cancer.

The update of uORFdb has been published by Nucleic Acids Research.